Archive for the ‘Baltimore’ Category

Tigers Bite

Posted by amanda on Wednesday, May 26th, 2010

Asian tiger mosquito, Aedes Albopictus

Asian tiger mosquito, Aedes Albopictus

Noticed anything new in the air lately? A high-pitched buzzing? Perhaps a six-legged, winged creature with a long proboscis out of the corner of your eye? The time of the mosquito is upon us. I received my first mosquito bite of the year the other day while innocently drinking my tea by the garden. I didn’t notice any stripes, but as the Asian tiger mosquito is now a well-established Maryland resident, I expect to see them soon.

Discovered in Maryland in 1987, the Asian tiger mosquito (Aedes albopictus) is an exotic species introduced to North America from Asia. Unlike the native Maryland mosquito, the Asian tiger is an extremely efficient carrier of viral disease. In 2001, tiger mosquitoes collected in Maryland tested positive for West Nile virus, a virus that mainly infects birds but can also infect humans and may result in flu-like symptoms or swelling of the brain. Only female mosquitoes bite, utilizing blood for egg development. Mosquitoes get most of their energy from flower nectar.

The best way to avoid mosquito bites is to eliminate mosquito breeding grounds. Tiger mosquitoes like to lay their eggs in pools of still water, especially in used tires. (Tires imported to Houston, Texas from Japan in 1985 may have brought tiger mosquitoes to the United States.) Here are some ways we can all work to reduce the number of mosquitoes we see this summer and the next:

  • Tip water out of barrels, buckets and wheelbarrows and turn them over so water cannot collect
  • Tip out containers that could hold water such as toys, cans or plant saucers weekly
  • Empty children’s wading pools weekly
  • Change water in birdbaths, pet watering dishes and animal troughs at least once a week
  • Get rid of old used tires
  • Clean debris from ornamental ponds and keep fountains running during the summer
  • Stock ornamental ponds with mosquito-eating fish, such as goldfish or koi
  • Maintain swimming pools and hot tubs
  • Recycle old bottles, buckets, and cans
  • Clean leaf-clogged gutters
  • Drain flat topped roofs
  • Dump water off of tarps and plastic sheeting
  • Drain water from covers on pools, boats and hot tubs
  • Repair leaky outdoor faucets
  • Cover rain barrels with mosquito screens
  • Cover garbage cans with an appropriate lid
  • Repair ripped window and door screens and make sure they fit tight; use a screen door on doors that often are left open
  • Fight the bite!

    Star Light, Star Really, Really Bright

    Posted by amanda on Friday, March 26th, 2010

    hubblep3-300x300

    NASA Hubble Space Telescope Collection

    The universe is expanding, and from far, far away in space and time, astronomers can see the formation of massive galaxies. These bright clusters of stars more than a few million light years away appear redder (or redshifted) than closer stars which helps in determining their distance and thus, time, in the development of the universe. Astronomers study these distant massive galaxies to better understand the timescale of galaxy formation and how galaxy shapes are formed, such as disks and bulges.

    Observation of some of these massive galaxies in the early Universe (known as sub-millimeter galaxies due to their wavelength, or high redshift) has revealed a very high rate of star formation, higher than expected from models. One hypothesis for this fast rate is the possibility of the merging of two gas-rich galaxies. Direct examination of the star-forming regions of these very distant galaxies has been difficult due to the limitations of modern-day telescopes.

    In a paper published this week online in Nature, a group of scientists, including two from the Department of Astronomy at the University of Maryland, use a unique solution to study one of these massive galaxies from the young Universe. By studying a sub-millimeter galaxy (known as SMMJ2135-0102), they took advantage of strong gravitational lensing that magnifies the galaxy from the bending of light by massive galaxy clusters that lie behind them. With this magnification, they then used high-resolution sub-millimeter imaging to resolve the star-forming regions at a linear scale of only 100 parsecs (one parsec is about 3.26 light years or 31 trillion kilometers), only slightly higher than the resolution of viewing giant molecular clouds in our own Milky Way.

    By comparing brightness and size between the high redshift galaxy and local galaxies and molecular clouds in the present-day Universe, the researchers found that the star forming region was not only 100 times larger, but also 100,000,000 times brighter. And although the star-forming energetics are much higher than local galaxies, the underlying physics of the processes are the same. Because the physics are similar, this means that techniques used for star-forming processes in the Milky Way can be used for sub-millimeter galaxies.

    So physics has not changed between the early Universe and the present-day Universe — young Universe galaxies are just really, really big, bright, and productive.

    Florence Sabin

    Posted by amanda on Monday, March 8th, 2010

    Today is International Women’s Day, where women are celebrated globally for their economic, social, political, and scientific achievements. This post is in continuation of my own celebration of National Women’s History Month.
    ——————————–

    Florence Sabin

    Florence Rena Sabin’s life was full of firsts. In 1896, after saving up money for 3 years as a schoolteacher, Florence Rena Sabin enrolled in Johns Hopkins Medical School. From a mining town in Colorado, Sabin was the first woman to graduate with an M.D. from Johns Hopkins. After graduation, she joined the Department of Anatomy with the support of a fellowship from the Baltimore Association for the Promotion of University Education of Women. She was the first woman faculty member at Johns Hopkins, the first woman to hold the rank of full professor, the first woman president of the American Association of Anatomists, the first woman elected to membership in the National Academy of Sciences, and the first woman to be appointed a full member at the Rockefeller Institute. In her obituary in the British Medical Journal, she was referred to as “the greatest living woman scientist and one of the foremost scientists of all time”.

    Her research contributed more than a hundred papers to the literature on the lymphatic system, tuberculosis, blood vessels, cells, and connective tissue. Contrary to popular belief at the time, Sabin demonstrated that the lymphatic system structure was formed from an embryo’s veins rather than from other tissues. Among her other research, she perfected a cell staining technique use to visualize live cells. As a scientist at the Rockefeller Institute, she made major contributions to the understanding of the human immune response to tuberculosis.

    Upon accepting the Pictorial Review achievement award in 1929, Sabin said:

    I hope my studies may be an encouragement to other women, especially to young women, to devote their lives to the larger interests of the mind. It matters little whether men or women have the more brains; all we women need to do to exert our proper influence is just to use all the brains we have.

    Rest assured, Dr. Sabin, you are an encouragement.

    See the National Library of Medicine for a more detailed biography of Sabin.

    Regression in the Dark

    Posted by amanda on Friday, March 5th, 2010

    Why don’t humans have tails or gills? Why aren’t we covered in hair? Why don’t we have all the traits of our primitive ancestors? When we think of the advance of evolution, we may think of increasing complexity, but many traits are lost due to regressive evolution. Regressive evolution is the disappearance of an ancestral trait or characteristic over time.

    Surface FishCavefish

    A. mexicanus Surface Fish and Cavefish; Courtesy of William Jeffery

    In order to better understand how regressive evolution occurs, scientists have found a model organism among cave-dwelling animals. Cavefish, like most cave-dwelling animals, have lost their eyes and pigmentation over time. And interestingly, they can interbreed with their surface-dwelling counterparts who still have eyes and normal pigment, making them a model tool for understanding the genetics of trait loss.

    How are traits lost in evolution? It may be that genes responsible for these traits are mutated or lost due to their lack of advantage. Or perhaps it is somehow more beneficial to not have the lost trait due to energy conservation. A third theory is that lost traits may be negatively linked to other traits that now benefit the organism in a new environment. When one gene affects many traits, this is known as pleiotropy.

    In a recent review in the journal Annual Review of Genetics, William Jeffery, a professor at the University of Maryland’s Department of Biology, discusses regressive evolution in the cavefish Astyanax mexicanus. Known as the Blind Tetra, A. mexicanus is native to 30 known caves in Mexico but can now be found in laboratories around the United States due to its short reproduction time, simple diet, and frequent spawning. Although cavefish appear eyeless, they actually have small nonfunctional eyes in a smaller eye socket completely covered with skin. In Jeffery’s lab, when a cavefish embryo is transplanted with a surface fish lens, the cavefish is able to develop an eye, containing a retina lacking pigment. The lens of the eye prevents cell death in the retina. Because the surface fish lens was able to rescue eye development, this suggests that the lens has a fundamental role in regulating eye degeneration and may be the crucial trait that is lost in the regressive evolution of eyesight.

    From genetic studies, it is estimated that up to twelve separate genes are responsible for eye loss. One of these genes (known as shh), affects both eye degeneration and the enhancement of oral and taste bud development, traits that would be advantageous to a cave-dwelling fish. This indicates that pleiotropy may play a role in eye regressive evolution. Jeffery stresses that more than one of the three possible theories for regressive evolution may be responsible for eye loss in cavefish. The search to identify all of the genes that affect eye degeneration in A. mexicanus is underway and may lead to insights about our own regressive evolution.

    I wish I could trade in my spleen for a tail…

    Henrietta Lacks

    Posted by amanda on Tuesday, March 2nd, 2010

    March is National Women’s History Month. In celebration, I plan to make one post a week featuring women that contributed significantly to science in Baltimore.

    Immortal Life of Henrietta Lacks

    I want to start with Henrietta Lacks, a woman from Turner Station whose cancerous cells were taken and turned into one of the most powerful scientific tools we have today. The tumorous cells that were removed from Henrietta’s cervix at Johns Hopkins Hospital during her treatment in 1951 were the first immortal human tissue cells to be cultured. First grown in the lab of George and Margaret Gey, Henrietta’s cells can be maintained indefinitely and have been used for countless experiments to study everything from cancer to the effects of atomic radiation on human tissue. Named HeLa, these cells led to advances in human genetics, such as the numbering of chromosomes, as well as to the cell culture, cloning, and in vitro fertilization methods we use today.

    The Immortal Life of Henrietta Lacks by Rebecca Skloot is an excellent read on the history of Henrietta and HeLa cells and highlights the moral and legal dilemmas of tissue collection. In her book, Skloot discusses how the Lacks family (who still reside in Baltimore) did not know about the use of HeLa cells until decades after their spread into laboratories around the world, and that while biotechnology companies that produce and sell HeLa continue to profit, the Lacks family has struggled with affording health insurance.

    According to Skloot, there has never been an official effort by Johns Hopkins to honor Henrietta Lacks and her biological contribution to science. With the amazing press Skloot’s book has generated, I have a feeling this may change soon.

    What’s in YOUR Water?

    Posted by amanda on Sunday, February 28th, 2010

    water drop

    http://www.flickr.com/photos/hypergurl/ / CC BY-NC 2.0

    In an article published last week in Current Opinion in Pediatrics, a well-respected professor at Mount Sinai School of Medicine in New York, Philip Landrigan, talks about the environmental chemicals implicated in neurodevelopmental disabilities. He discusses the possibility that environmental toxins may be contributing to autism, alerting the scientific community to the need for more research on the effects of common chemicals on brain biology. In his article, he states that synthetic chemicals that are ubiquitous at hazardous waste sites are commonly found in our air, food, and drinking water. And fewer than 20% of these have been tested for brain developmental toxicity.

    As I sat reading the article, drinking my cup of tap water tea, I asked myself: What’s in your water?

    According to the Environmental Working Group, a watchdog organization that compiles data from water utility companies and state departments, Baltimore ranks 69 out of 100 cities for quality of water with 1 being the best and 100 the worst. The list of chemicals found in the Baltimore City Department of Public Works water is astounding. In the past five years, two contaminants were found to be above legal limits with eleven others above health guidelines. A total of 22 pollutants were identified in Baltimore City water, 14 more than the national average. 22!

    Let’s do a rundown on some of them:

    • Lead: Even my 2-year old daughter knows this one is bad. The EPA has a restriction of 15 ppb for drinking water, and levels above that value (at 19.3 ppb) were detected in Baltimore City water in the past 5 years with an average of 5.16 ppb overall. Lead is known to cause brain damage.
    • Total haloacetic acids (HAAs), Total trihalomethanes (TTHMs), Chloroform, Bromoform, and Trichloroacetic acid: Disinfectants that cause DNA damage and cell death. Carcinogens aplenty. Both HAAs and TTHMs were found above legal limits during the past 5 years. In fact, Baltimore City water ranks among the top 10 cities with the highest levels of TTHMs (at an average of 44.5 ppb).
    • Alpha Particle Activity and Radium-226: Radioactive. Any chemical with a number after it is generally bad. Luckily, the data is from only one test and is at very low levels that we probably don’t need to worry about.
    • Di(2-ethylhexyl) phthalate: Phthalates, found in soft plastics, have been in the news for awhile now, so you probably have heard their name. They are beginning to be phased out of products in both the United States and Europe due to their toxicity.  Phthalates can cause both reproductive and developmental problems. The level in Baltimore City water is at an average of 0.85 ppb. The danger lies in a build-up of phthalates within the body over time.

    In his article, Landrigan stresses that in the examples of known chemicals that are relevant to autism (where women were taking certain medications that lead to a higher incidence of autism in their children, such as thalidomide, misoprostol, and valproic acid), exposure occurs prenatally, very early in the first trimester of pregnancy. Therefore, this may be the most important time to avoid harmful chemicals that can affect fetal brain development. Whether or not other chemicals or known neurotoxins, such as phthalates, organophosphate pesticides, and BPA, cause an increase in autism or other specific brain development disorders is not known, and Landrigan encourages future toxicological studies to answer these questions.

    But I know one thing for sure: I’m off to get a water filter.

    Clearing the Water

    Posted by amanda on Tuesday, February 16th, 2010

    K. veneficum

    Karlodinium veneficum aka Gymnodinium galatheanum aka Karlodinium micrum; Courtesy of Prof. Allen Place

    There’s a predator in Maryland waters. In 1996, 1997, and 1999, thousands of fish were killed at the HyRock Fish Farm on the Eastern Shore of the Chesapeake Bay. Water samples revealed the presence of two potential culprits, and after an initial case of mistaken identity, Karlodinium veneficum (then called Gymnodinium galatheanum) was found to be the cause. K. veneficum, a free-swimming phytoplankton or dinoflagellate, was first identified in Walvis Bay, Namibia in 1950 during the second Danish “Galathea” Deep Sea expedition. In South Africa, it caused periodic massive fish deaths, leaving the beaches covered with rotting fish and turning the water red with its thick algal blooms (colloquially known as red tide). In 2008, five fish kills in Chesapeake Bay and the Potomac occurred due to the presence of K. veneficum. This algae species is now considered a long term resident of Chesapeake Bay, and blooms (sometimes resulting in a “mahogany tide”) are monitored by the Maryland Department of Natural Resources.

    Map of Algal Cell Counts on 6/29/09

    Map of algal cell counts in the Bay on 6/29/09, K. veneficum marked by green triangles; Maryland DNR

    Like many dinoflagellates, K. veneficum produces toxins, known as karlotoxins. Karlotoxins causes cells to rupture by increasing the ionic permeability of biological membranes (making them leaky until they explode). Fish are killed by damage to the gill epithelia. K. veneficum can gain energy both by photosynthesis and by the consumption of single-celled organisms. The production of toxins was hypothesized to be a self-defense system against other organisms in the phytoplankton grazing territory with local fish as the unlucky bystanders. Karlotoxins were identified and characterized in the lab of Allen Place of the Institute of Marine and Environmental Technology at the University of Maryland Center for Environmental Science.

    In the February 2nd issue of the Proceedings of the National Academy of Sciences, Place and colleagues from the University of Minnesota, The Johns Hopkins University and the University of Hawaii show that karlotoxins are not just used by K. veneficum in self-defense. The toxic predatory strains use karlotoxins as a means of stunning their cryptophyte prey (Storeatula major) before ingesting it. Thus, the presence of prey leads to the presence of toxin. Therefore, by reducing the amount of K. veneficum prey in the Chesapeake and other infected waterways, K. veneficum may produce less toxin, leaving the fish to swim in peace.

    Prey reduction (in conjunction with the input of native feeders) may help in developing effective management strategies against other predatory dinoflagellates in Maryland waters. According to the Maryland Department of the Environment, another dinoflagellate, Gyrodinium uncatenum, caused the largest fish kills in the state in 2008, resulting in 142,365 fish deaths. Unlike K. veneficum, G. uncatenum is non-toxic, and fish kills are thought to be caused by low dissolved oxygen produced from the large algal blooms. Like K. veneficum, G. uncatenum could gain energy from photosynthesis alone, but a reduction in prey may reduce the size of algal blooms and fish deaths.

    How dinoflagellate prey reduction will be implemented without damaging the Bay ecology or industry is another scientific challenge that I hope I will have the pleasure of blogging about someday.

    Studying the Sun

    Posted by amanda on Saturday, February 13th, 2010

    UV image of the sun

    Ultraviolet image of the Sun; Credit: NASA

    While many of us were huddled at home during last week’s snowstorm, some employees at NASA Goddard Space Flight Center in Greenbelt were preparing for a mission of cosmic proportions. On February 11th, the Atlas V launched from Cape Canaveral to send the Solar Dynamics Observatory (SDO) into space on its mission to better understand the sun. Although no shuttles or satellites are actually launched in Maryland, Goddard provides critical mission support for shuttle launches and missions like SDO from its Mission Operation Center and Network Integration Center. In the lead up to a mission, the center is staffed 24 hours a day as they prepare for a launch.

    Layers of the Sun

    Layers of the Sun; Credit: NASA

    Although it is the center of our solar system and our closest star, there is still much to learn about the Sun. We know the Sun is a ball of gas composed of the same elements found on Earth (mainly hydrogen and helium) that get denser as they move inward to the Sun’s core. We also know it is composed of distinct layers, but we can only observe the Sun’s outer layers directly. These include the deepest layer we can see, the photosphere, the next outer layer, the chromosphere, and the outermost region of the atmosphere, the corona, which can be viewed as a halo during an eclipse. Although temperature generally decreases as you move out from the core of the Sun, the chromosphere can reach temperatures higher than the photosphere, and the corona can reach millions of Kelvin. The corona is so hot that the majority of radiation is emitted at ultraviolet and X-ray wavelengths. (The atmosphere of the Earth can block most of this light, which is why we aren’t constantly sunburned.) We don’t yet understand why the corona is so hot. It may be because of the Sun’s magnetic field, but the mechanism is still unknown.

    Most important to space weather (and therefore, Earth weather) is the Sun’s solar activity, which is measured by the amount of sunspots present on the Sun. Sunspots are cooler regions on the Sun’s photosphere and so appear to be darker than the photosphere. Although sunspots are locally cooler, their presence is associated with greater overall solar temperatures. They form in cycles of an average of 11.1 years, where at the maximum over 100 sunspots can be seen, and sometimes no spots are observed at the minima. The cycle of sunspots is closely related to the magnetism of the Sun and form in regions of intense magnetic activity. Solar flares and coronal mass ejections, large explosions in the Sun’s atmosphere, often occur in these magnetically intense areas. During extended periods of low solar activity, the Earth can experience cold temperatures (such as during the Little Ice Age in the 17th century).

    The NASA Goddard-managed SDO will aid in understanding the Sun’s magnetic changes. The spacecraft is built to fly for five years but will probably outlast itself like previous satellites. SDO is the first satellite to launch under the Living With a Star program at NASA aimed to understand the relationship of the Sun to space weather. By measuring the properties of the Sun and solar activity, SDO plans to determine how the magnetic field is generated and structured and how the stored magnetic energy is released outward from the Sun into space. SDO data and analysis will be used to help predict the solar variations that influence life on Earth. Among other things, SDO will examine sunspots, solar flares, and coronal mass ejections like the one observed less than a month ago from another Goddard-associated satellite:

    YouTube Preview Image

    STEREO satellite movie from NASA

    We could certainly use more of the Sun around Baltimore right now.

    For more detailed explanations of the Sun and its properties, see NASA or Wikipedia.

    The City That Researches

    Posted by amanda on Monday, February 8th, 2010

    Baltimore is a city of science. Many of us are educators, students, researchers, engineers, and technicians. We work at hospitals, schools, libraries, and government research institutions. Baltimoreans are surrounded by some of the greatest research in the country. From Johns Hopkins University to NASA Goddard to the University of Maryland. “The City That Reads” is a misnomer. Baltimore is “The City That Researches”.

    On Bmore Scientific, I plan to talk about the global science research that affects our city and to highlight the science that’s being done in Maryland. When I first moved here, I was amazed at how little science was in Baltimore media except the various research entities’ PR publications. I want Baltimore to be proud of its science.  Science is inherently exciting! So stay tuned…